This hearty, bubbling Cattle Drive Casserole layers seasoned ground beef and melted cheese over a buttery biscuit base that bakes up golden and soft. I first made this on a chilly Tuesday when I needed something filling and easy, and now it's one of those recipes I turn to when I want the whole family around the table.

The Tex-Mex flavors remind me of my favorite Chicken Kofta Kebabs but with that cozy, casserole comfort you get from dishes like Fettuccine Alfredo. If you're craving something cheesy and satisfying, maybe pair it with a lighter side like Gambas al Ajillo for contrast.
Why You'll Love This Cattle Drive Casserole
This easy Cattle Drive Casserole doesn't ask much from you, but it delivers big flavor. The biscuit crust bakes right in the pan, so there's no rolling or fussing. The ground beef gets coated in taco seasoning and simmered with fire-roasted tomatoes and green chilies, which gives it a little smoky kick without being spicy.
The creamy topping is a mix of mayo, sour cream, and cheese that melts into the beef while everything bakes. It's rich, it's cheesy, and it holds together beautifully when you scoop it onto plates. My neighbor Hannah tried it last month and said her kids asked for it again the next week, which is always a good sign.
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Cattle Drive Casserole Ingredients
Here's what you'll need to make this cheesy Cattle Drive Casserole recipe.
See Recipe Card Below This Post For Ingredient Quantities
For the biscuit base:
- Red Lobster Cheddar Bay Biscuit Mix : This creates a buttery, cheesy foundation that bakes up soft and golden. The seasoning packet adds extra flavor right into the crust.
- Cold water : Brings the biscuit dough together. Cold water helps keep the texture light.
For the beef layer:
- Ground beef : The hearty base of the casserole. Lean ground beef works well, but 80/20 adds more flavor.
- Onion : Adds sweetness and depth as it cooks down with the beef.
- Taco seasoning : Brings all the Tex-Mex flavor-cumin, chili powder, garlic, and a little heat.
- Water : Helps the taco seasoning coat the beef evenly and creates a bit of sauce.
- Fire-roasted diced tomatoes : Adds a smoky, slightly charred flavor that makes this taste special. Draining them keeps the casserole from getting watery.
- Diced green chilies : Brings a mild, tangy heat. Leaving them undrained adds moisture and flavor to the beef.
For the creamy topping:
- Mayonnaise : Creates richness and helps the topping spread smoothly over the beef.
- Sour cream : Adds tang and creaminess. Balances the richness of the mayo.
- Shredded Colby Jack cheese : Melts beautifully and adds a mild, creamy flavor. You'll use 1 cup in the topping and 1 cup sprinkled on top.
Optional garnish:
- Dried parsley flakes : Adds a pop of color and a hint of freshness.
How to Make Cattle Drive Casserole
This Cattle Drive Casserole comes together in simple steps.
Preheat and prep: Preheat your oven to 375°F. Lightly spray a 9x13-inch casserole dish with nonstick cooking spray so nothing sticks.
Make the biscuit base: In a medium bowl, combine the Red Lobster Cheddar Bay Biscuit Mix (including the seasoning packet) and ¾ cup cold water. Stir until just combined-don't overmix. Spread the dough evenly across the bottom of your prepared casserole dish. If the dough is sticky, spray your hands with a little cooking spray and gently press it out.

Parbake the crust: Bake for 5 to 8 minutes, or until the dough is set but not fully cooked. It should look dry on top and firm to the touch. Remove from the oven and set aside.
Cook the beef: In a large skillet over medium heat, cook the ground beef with the diced onion, breaking up the meat as it cooks. Once the beef is browned and the onion is soft, drain any excess grease if needed.

Add the seasonings: Stir in the taco seasoning, ¼ cup water, drained fire-roasted diced tomatoes, and undrained diced green chilies. Let the mixture simmer for 2 to 3 minutes, stirring occasionally. The beef should be coated and fragrant.
Layer the beef: Spread the beef mixture evenly over the partially baked biscuit layer. Use a spoon or spatula to spread it all the way to the edges.
Make the creamy topping: In a small bowl, combine the mayonnaise, sour cream, and 1 cup shredded Colby Jack cheese. Stir until smooth. Spread this mixture evenly over the beef layer-it doesn't have to be perfect, just mostly even.
Add the cheese: Sprinkle the remaining 1 cup shredded Colby Jack cheese over the top. It'll melt into a golden, bubbly layer.
Bake: Bake for 30 minutes, or until the top is melted, bubbly, and lightly golden around the edges. The cheese should be fully melted and the casserole should smell amazing.
Cool and garnish: Remove from the oven and let it cool for 5 minutes before serving. This helps everything set so it's easier to scoop. Garnish with dried parsley flakes if you like.
Equipment For Cattle Drive Casserole
- 9x13-inch casserole dish: The right size for this recipe. Glass or ceramic works great.
- Large skillet: For browning the beef and building the filling.
- Medium bowl: To mix the biscuit dough.
- Small bowl: For combining the creamy topping.
- Nonstick cooking spray: Keeps everything from sticking.
Substitutions and Variations
Biscuit mix: If you can't find Red Lobster biscuit mix, you can use Bisquick and add a little shredded cheddar and garlic powder. The texture will be slightly different but still good.
Ground beef: Swap in ground turkey, ground chicken, or even plant-based crumbles. Just adjust the seasoning since leaner meats can taste a little milder.
Taco seasoning: Make your own with chili powder, cumin, garlic powder, onion powder, paprika, and a pinch of cayenne.
Fire-roasted tomatoes: Regular diced tomatoes work fine, but you'll lose that smoky depth. You could add a pinch of smoked paprika to make up for it.
Cheese: Use sharp cheddar, Monterey Jack, or a Mexican blend instead of Colby Jack. They all melt well.
Cornbread version: Some people make this with a cornbread base instead of biscuits. You can use a cornbread mix and follow the same layering method for a sweeter, crumblier crust.
Storage and Reheating
Refrigerator: Store leftovers in an airtight container or cover the casserole dish tightly with foil. It'll keep for 3 to 4 days in the fridge.
Freezer: You can freeze this Cattle Drive Casserole before or after baking. Wrap it tightly in plastic wrap, then aluminum foil. It'll keep for up to 3 months. Thaw overnight in the fridge before reheating.
Reheating: Warm individual portions in the microwave for 1 to 2 minutes, or reheat the whole casserole covered with foil in a 350°F oven for 20 to 25 minutes until heated through.
Serving Suggestions
This comfort food Cattle Drive Casserole is filling on its own, but here are a few ideas to round out the meal:
- Serve it with a crisp green salad tossed in lime vinaigrette to balance the richness.
- Add a side of black beans or refried beans for extra protein.
- Top each serving with a dollop of sour cream, sliced green onions, or a drizzle of hot sauce.
- Pair it with tortilla chips and fresh salsa for scooping, almost like nachos on a plate.
If you're looking for something lighter to serve alongside, try Tuna Melt Wrap or a simple rice dish like Chicken Pulao.
Expert Tips
Don't skip the parbake: Baking the biscuit layer first keeps it from getting soggy under all that beef and cheese.
Drain the tomatoes: Fire-roasted tomatoes have great flavor, but they also have a lot of juice. Draining them keeps the casserole from turning watery.
Use room temperature dairy: Let the sour cream and mayo sit out for a few minutes before mixing. They'll blend more smoothly.
Let it rest: Give the Cattle Drive Casserole 5 minutes to cool after baking. It makes slicing and serving so much easier.
Customize the heat: If you like it spicier, add a diced jalapeño to the beef or use hot taco seasoning. If you want it milder, skip the green chilies or use just half the can.
Make it ahead: You can assemble the whole casserole, cover it, and refrigerate it for up to 24 hours before baking. Just add 5 to 10 extra minutes to the bake time if you're starting from cold.
FAQ
What is Cattle Drive Casserole?
Cattle Drive Casserole is a layered Tex-Mex bake with a biscuit crust, seasoned ground beef, and a creamy cheese topping. It's hearty, easy to make, and perfect for feeding a crowd. The name comes from the cowboy-style, ranch-inspired flavors.
What is Dolly Parton's five ingredient casserole?
Dolly Parton's casserole is a simple dump-and-bake chicken dish made with cream of chicken soup, sour cream, Ritz crackers, butter, and chicken. It's different from Cattle Drive Casserole, which uses beef, biscuits, and Tex-Mex seasonings instead.
Why is it called a John Wayne casserole?
John Wayne casserole got its name from the cowboy actor and is usually made with layers of biscuits, beef, cheese, and sometimes beans. It's similar to Cattle Drive Casserole but often includes sour cream mixed right into the beef layer. Both are hearty, Western-style comfort foods.
What's the secret to a good casserole?
The secret is layering flavors and textures, and making sure nothing gets soggy. Parbake any crust, drain wet ingredients like tomatoes, and let the Cattle Drive Casserole rest before serving so everything sets. A good casserole should hold together when you scoop it and taste balanced in every bite.
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Pairing
These are my favorite dishes to serve with Cattle Drive Casserole

Cattle Drive Casserole
Ingredients
- 1 box Red Lobster Cheddar Bay Biscuit Mix including the seasoning packet
- ¾ cup cold water for biscuit mix
- 1 pound ground beef or preferred ground meat
- 1 medium onion diced adds flavor and texture
- 1 packet taco seasoning for flavoring
- ¼ cup water to mix with taco seasoning
- 14.5- ounce can fire-roasted diced tomatoes drained adds smokiness
- 4- ounce can diced green chilies undrained for spice
- ½ cup mayonnaise creamy base for the sauce
- ½ cup sour cream adds tanginess to the sauce
- 2 cups shredded Colby Jack cheese divided creamy cheese blend
- 1 teaspoon dried parsley flakes optional for garnish
Instructions
- Preheat the oven to 375°F. Lightly grease a 9x13-inch casserole dish with nonstick cooking spray.
- In a medium bowl, combine 1 box Red Lobster Cheddar Bay Biscuit Mix (including the seasoning packet) and ¾ cup cold water. Stir until just combined. Spread the dough evenly across the bottom of the casserole dish, pressing down lightly. If it's too sticky, spray your hands with cooking spray for easier handling.
- Bake the biscuit dough for 5-8 minutes, just until it sets. Remove from the oven and set aside.
- In a medium skillet, cook 1 pound ground beef and 1 diced medium onion over medium heat, breaking up the meat as it cooks. Once the beef is browned, drain any excess grease.
- Add 1 packet taco seasoning, ¼ cup water, 14.5-ounce can fire-roasted diced tomatoes (drained), and 4-ounce can diced green chilies (undrained) to the skillet. Stir well and let simmer for 2-3 minutes.
- Spread the beef mixture evenly over the partially baked biscuit layer in the casserole dish.
- In a small bowl, mix ½ cup mayonnaise, ½ cup sour cream, and 1 cup shredded Colby Jack cheese. Spread this mixture evenly over the beef layer.
- Sprinkle the remaining 1 cup shredded Colby Jack cheese over the top of the casserole.
- Bake the casserole for 30 minutes or until the top is melted and bubbly. Remove from the oven and allow to cool for 5 minutes. Garnish with 1 teaspoon dried parsley flakes, if desired.













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